Spontaneous Gamma Activity in Schizophrenia

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Spontaneous Gamma Activity in Schizophrenia.

IMPORTANCE A major goal of translational neuroscience is to identify neural circuit abnormalities in neuropsychiatric disorders that can be studied in animal models to facilitate the development of new treatments. Oscillations in the gamma band (30-100 Hz) of the electroencephalogram have received considerable interest as the basic mechanisms underlying these oscillations are understood, and ga...

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Gamma Oscillation in Schizophrenia

Dysfunctional neural circuitry has been found to be involved in abnormalities of perception and cognition in patients with schizophrenia. Gamma oscillations are essential for integrating information within neural circuits and have therefore been associated with many perceptual and cognitive processes in healthy human subjects and animals. This review presents an overview of the neural basis of ...

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Gamma oscillations and schizophrenia.

In the last 2 decades, it has become apparent that brain regions communicate by coordinating the firing of populations of neurons. When neurons synchronize their firing, their rhythmic input is reflected in the extracellular field potential as brain oscillations. Rhythmic brain activity in animals and humans can be recorded using noninvasive techniques such as electroencephalography (EEG) by pl...

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BACKGROUND The early visual-evoked gamma oscillation (VGO) elicited by Gestalt stimuli is reduced in schizophrenia patients compared with healthy individuals, but it is unknown whether this effect is specific to these particular stimuli and task. In contrast, the early auditory-evoked gamma oscillation (AGO) was reported to be unaffected in a sample of unmedicated, mostly first-episode schizoph...

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ژورنال

عنوان ژورنال: JAMA Psychiatry

سال: 2015

ISSN: 2168-622X

DOI: 10.1001/jamapsychiatry.2014.2642